Osaka Soda provides the revolutionary polymer-coated “capsule type” HPLC column with combined advantages of silica-based and polymer-based columns.
CAPCELL PAK is an epoch-making HPLC column integrating the excellent separation performance of silica-based packing material and the high chemical stability of polymer-based packing material.
CAPCELL PAK columns show tremendous durability and reproducibility, being free from undesirable secondary effects typical of other silica-based columns. Their unique synthetic process consists of two steps.
1) Surface coating of the silica using a silicone monomer by vapor deposition, resulting in a homogenous polymeric mono-layer.
2) Attaching alkyl groups to the coated surface that shields acidic silanols.
Characteristics of Packing Material by Support Type
Silica packing materials, represented by octadecylsilyl (ODS-) silica and octylsilyl silica, have numerous features such as excellent pressure resistance and solvent resistance, high separation performance, wide sample range, and low column cost. But, it is known that C18 groups are hydolyzed in basic environments, and that silica itself dissolved into basic liquid. Therefore, conventional ODS columns’ mobile phase were limited to acidic or neutral.
By applying surface treatment technology that is cultivated in the research of powdery materials used for cosmetics, Shiseido successfully developed a novel polymercoated packing material (capsule) in 1985 (received the Chemical Technology Award from the Chemical Society of Japan). This technology features:
- Polymer coating of a uniform thickness along the pores of silica
- Excellent chemical stability by polymer coating
- Polymer coating deactivates residual silanols which cause peak tailing
- Extended pH range (1-10)
- Provides longer lifetime
- Durable and reproducible
- Low column pressure
- Excellent selectivity
- Available in many popular phases
- GLP/GMP validation supported (UG, MG series)
To consistently obtain stable analytical results from any lot anywhere in the world, CAPCELL PAK is subject to thorough quality control at each production process from choice of starting materials to shipping.
Most CAPCELL PAK columns are classified not only by application based on the Pharmaceutical Affairs Law of Japan but also by USP category from the United States Pharmacopeia. These columns support worldwide applications. Columns of stable quality are available at any time anywhere in the world and can be used for routine analysis.
Capsule-type shielding via 0.7nm silicone polymer layer
AG: conventional, mono-layer polymer coating, pH 2-10
SG: high purity, mono-layer polymer coating, pH 2-9
UG: high purity, homogeneous mono-layer polymer coating, pH 2-10
MG: high purity, controlled homogeneous mono-layer polymer coating, pH 2-10
CAPCELL CR Strong Cation-Exchange mixed with C18 (Reversed Phase) Ceramospher New type of column for chiral separations with optically active metal complex on porous spherical ceramics by cation exchange.
RU-1 stable up to 20MPa and 20-60°C (methanol type)
RU-2 aqueous mobile phase possible, stable up to 20 MPa and 15-60°C (water/methanol type)
Proteonavi C4 phase especially for protein retention
PC HILIC Silica-based HILIC column with phosphorylcholine (PC)
Jl. RC. Veteran Raya No.9, Bintaro, Jakarta Selatan, DKI Jakarta 12330
AMG Tower Room B03-B, 8th Floor.
Jl. Dukuh Menanggal 1-A, Gayungan, Surabaya-60234
Telp: 021 22734544
Fax: 021 7371105