Osaka Soda

The revolutionary polymer-coated “capsule type” HPLC column with combined advantages of silica-based and polymer-based columns

OSAKA SODA CO., LTD. is a Japan-based chemical manufacturer.

Osaka-Soda™ is manufacturing ultra-shielded Capcell Pak UHPLC & HPLC-Columns based on proprietary silicone polymer coating technology. Previously, the columns belonged to the Shiseido™ Company, whose chromatography division was acquired by Osaka Soda in 2017. The technology of Capcell Pak columns combines the advantages of silica and polymer columns and reduces residual silanols which cause peak tailing. Capcell Pak columns are stable in pH range 1-10 and can be used under harsh mobile phases.

Another features:

1. Polymer coating deactivates residual silanols which cause peak tailing
2. Extended pH range (1-10) provides longer lifetime
3. Durable and reproducible
4. Low column pressure
5. Excellent selectivity
6. Available in many popular phases
7. GLP/GMP validation supported (UG, MG series)

As an authorized dealer of Osaka Soda in Indonesia we can supply the complete range of Osaka Soda columns below:

1. CAPCELL CORE
   Polymer coated core shell particle of 2.7µm with a core of 1.7µm and a porous coat of 0.5µm (pH= 1.5-10)
2. CAPCELL PAK
   capsule-type shielding via 0.7nm silicone polymer layer

• AG: conventional, mono-layer polymer coating, pH 2-10
• SG: high purity, mono-layer polymer coating, pH 2-9
• UG:  high purity, homogeneous mono-layer polymer coating, pH 2-10
• MG: high purity, controlled homogeneous mono-layer polymer coating, pH 2-10

Reinforced homogeneous mono-layer polymer coating:

• MG-II: high purity, pH 2-10
• MG-III: high purity,  pH 2-10, LC-MS
• ACR:  high purity,  pH 1-10
• DD:  high purity,  pH 1.5-10
• AQ:  high purity, pH 2-9
• IF2: 2.2 µm UHPLC, high pressure stability up to 100 MPa
• IF: 2 µm, =Ideally Fine Particle, pressire stable up to 40 MPa
• NEW: ADME-HR:  with Adamantyl group for retention of polar substances.

3. CAPCELL CR Strong Cation-Exchange mixed with C18 (Reversed Phase)
4. Ceramospher  New type of column for chiral separations with optically active metal complex on porous spherical ceramics by cation exchange

• RU-1 stable up to 20MPa and 20-60°C (methanol type)
• RU-2 aqueous mobile phase possible, stable up to 20 MPa and 15-60°C (water/methanol type)

5. Proteonavi  C4 phase especially for protein retention
6. PC HILIC: Silica-based HILIC column with phosphorylcholine (PC)

 

Capcell Pak columns provide reversed-phase, normal-phase and HILLC (Reverse of reversed-phase) modes ion-exchange separation modes. The following guide will help chromatographers to choose a suitable column that best fits their applications.

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Silica packing materials, represented by octadecylsilyl (ODS-) silica and octylsilyl silica, have numerous features such as excellent pressure resistance and solvent resistance, high separation performance, wide sample range, and low column cost. But, it is known that C18 groups are hydolyzed in basic environments, and that silica itself dissolved into basic liquid. Therefore, conventional ODS columns’ mobile phase were limited to acidic or neutral.

By applying surface treatment technology that is cultivated in the research of powdery materials used for cosmetics, Shiseido successfully developed a novel polymercoated packing material (capsule) in 1985 (received the Chemical Technology Award from the Chemical Society of Japan). This technology features:

• Polymer coating of a uniform thickness along the pores of silica
• Excellent chemical stability by polymer coating
• Polymer coating deactivates residual silanols which cause peak tailing
• Extended pH range (1-10)
• Provides longer lifetime
• Durable and reproducible
• Low column pressure
• Excellent selectivity
• Available in many popular phases
• GLP/GMP validation supported (UG, MG series)

Capcell PAK

To consistently obtain stable analytical results from any lot anywhere in the world, CAPCELL PAK is subject to thorough quality control at each production process from choice of starting materials to shipping.

Most CAPCELL PAK columns are classified not only by application based on the Pharmaceutical Affairs Law of Japan but also by USP category from the United States Pharmacopeia. These columns support worldwide applications. Columns of stable quality are available at any time anywhere in the world and can be used for routine analysis.

Capsule-type shielding via 0.7nm silicone polymer layer
AG: conventional, mono-layer polymer coating, pH 2-10
SG: high purity, mono-layer polymer coating, pH 2-9
UG: high purity, homogeneous mono-layer polymer coating, pH 2-10
MG: high purity, controlled homogeneous mono-layer polymer coating, pH 2-10

Capcell Core

CAPCELL CR Strong Cation-Exchange mixed with C18 (Reversed Phase) Ceramospher New type of column for chiral separations with optically active metal complex on porous spherical ceramics by cation exchange.
RU-1 stable up to 20MPa and 20-60°C (methanol type)
RU-2 aqueous mobile phase possible, stable up to 20 MPa and 15-60°C (water/methanol type)
Proteonavi C4 phase especially for protein retention
PC HILIC Silica-based HILIC column with phosphorylcholine (PC)